Murine Model for Lymphocytic Tropism by Borrelia burgdorferi

Murine model for lymphocytic tropism by Borrelia burgdorferi.

In vitro studies have demonstrated direct interactions between Borrelia burgdorferi and human B and T cells. However, largely because disseminated infections typically occur at very low density, little is known about associations between spirochetes and mammalian host cells in vivo. To assess whether spirochetes interact directly with lymphocytes in mammals, we developed a mouse model for lymph...

Molecular Adaptation of Borrelia burgdorferi in the Murine Host

An analysis of expression of 137 lipoprotein genes on the course of murine infection revealed a two-step molecular adaptation by Borrelia burgdorferi, the Lyme disease spirochete. For the first step, regardless whether the initial inocula of B. burgdorferi expressed either all (cultured spirochetes) or less than 40 (host-adapted spirochetes) of the 137 lipoprotein genes, the spirochetes were mo...

Complement Evasion by Borrelia burgdorferi Spirochetes

INFeCtIONS CAUSeD BY BORRELIA BURGDORFERI SeNSU LAtO ZAKAŻENIA WYWOŁYWANE PRZEZ BORRELIA BURGDORFERI SeNSU LAtO

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Biofilm formation by Borrelia burgdorferi sensu lato.

Bacterial biofilms are microbial communities held together by an extracellular polymeric substance matrix predominantly composed of polysaccharides, proteins and nucleic acids. We had previously shown that Borrelia burgdorferi sensu stricto, the causative organism of Lyme disease in the United States is capable of forming biofilms in vitro. Here, we investigated biofilm formation by B. afzelii ...